The 30 year old Hawick rider started from pole position aboard the Rapid Solicitors and Monster Energy-backed PBM by The Venetian Hotel Kawasaki after edging out main rival Michael Rutter by over half a second in qualifying.
From there, the double British Supersport Champion and 2014 MCE BSB Rider's Cup Champion was never headed as he steadily built a lead, lapping over two seconds a lap faster than his rivals around the 6.12km Circuito Da Guia before rolling it off on the last lap to emerge victorious by over 14 seconds.
It was the Scot's fourth Macau GP victory, adding to his successes in 2008, 2009 and 2010 before serious injury saw him miss the 2011 race.
Easton's latest victory rounded off a very successful season for the Penrith-based PBM team which saw Shane 'Shakey' Byrne win the MCE British Superbike Championship, adding to Easton's Rider's Cup success.
Stuart Easton: "To come back after three years and win again is fantastic although I didn't expect it to be quite so easy. I knew my wife and my little boy were watching back home so I had to do it for them. It was a case of just getting my head down and building a lead and I was comfortable putting the laps in. Thanks to the team, this is a great way to end the season on a high."
Paul Bird: "It's brilliant to get another Macau GP win, that was a proper job! Stuart has been a class above everyone else here all week which is even more impressive when you consider he's not been here for three years. The others simply had no answer for him."